Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome - First-in-Human Pilot Study.

Abstract

BACKGROUND Hydrogen gas inhalation (HI) ameliorates cerebral and cardiac dysfunction in animal models of post-cardiac arrest syndrome (PCAS). HI for human patients with PCAS has never been studied. METHODSANDRESULTS Between January 2014 and January 2015, 21 of 107 patients with out-of-hospital cardiac arrest achieved spontaneous return of circulation. After excluding 16 patients with specific criteria, 5 patients underwent HI together with target temperature management (TTM). No undesirable effects attributable to HI were observed and 4 patients survived 90 days with a favorable neurological outcome. CONCLUSIONS HI in combination with TTM is a feasible therapy for patients with PCAS. (Circ J 2016; 80: 1870-1873).

DOI: 10.1253/circj.CJ-16-0127

Cite this paper

@article{Tamura2016FeasibilityAS, title={Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome - First-in-Human Pilot Study.}, author={Tomoyoshi Tamura and Kei Hayashida and Motoaki Sano and Masaru Suzuki and Takayuki Shibusawa and Joe Yoshizawa and Yosuke Kobayashi and Takeshi Suzuki and Shigeo Ohta and Hiroshi Morisaki and Keiichi Fukuda and Shingo Hori}, journal={Circulation journal : official journal of the Japanese Circulation Society}, year={2016}, volume={80 8}, pages={1870-3} }