Fear-reducing effects of intra-amygdala neuropeptide Y infusion in animal models of conditioned fear: an NPY Y1 receptor independent effect

  title={Fear-reducing effects of intra-amygdala neuropeptide Y infusion in animal models of conditioned fear: an NPY Y1 receptor independent effect},
  author={Markus Fendt and Hugo B{\"u}rki and Stefan Imobersteg and Kurt Lingenh{\"o}hl and Kevin H Mcallister and David Orain and Doncho P. Uzunov and Fr{\'e}d{\'e}rique Chaperon},
RationaleNeuropeptide Y (NPY) and its receptors are densely localized in brain regions involved in the mediation and modulation of fear, including the amygdala. Several studies showed that central NPY is involved in the modulation of fear and anxiety.ObjectivesIn the present study, we investigated (1) whether intra-amygdala injections of NPY affect the expression of conditioned fear and (2) whether NPY Y1 receptors (Y1R) mediates the effects of these intra-amygdaloid NPY injections.ResultsIntra… 

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