Fear learning and extinction are linked to neuronal plasticity through Rin1 signaling.

@article{Bliss2010FearLA,
  title={Fear learning and extinction are linked to neuronal plasticity through Rin1 signaling.},
  author={Joanne M. Bliss and Erin E. Gray and Ajay Dhaka and Thomas J O'Dell and John Colicelli},
  journal={Journal of neuroscience research},
  year={2010},
  volume={88 4},
  pages={917-26}
}
The amygdala is known to have a crucial role in both the acquisition and extinction of conditioned fear, but the physiological changes and biochemical mechanisms underlying these forms of learning are only partly understood. The Ras effector Rin1 activates Abl tyrosine kinases and Rab5 GTPases and is highly expressed in mature neurons of the telencephalon including the amygdala, where it inhibits the acquisition of fear memories (Rin1(-/-) mice show enhanced learning of conditioned fear). Here… CONTINUE READING

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