Fear conditioning and LTP in the lateral amygdala are sensitive to the same stimulus contingencies

@article{Bauer2001FearCA,
  title={Fear conditioning and LTP in the lateral amygdala are sensitive to the same stimulus contingencies},
  author={Elizabeth P. Bauer and Joseph E LeDoux and Karim Nader},
  journal={Nature Neuroscience},
  year={2001},
  volume={4},
  pages={687-688}
}
Pavlovian fear conditioning depends not so much on the contiguity (temporal overlap) of the conditioned stimulus (CS) and unconditioned stimulus (US) as on contingency, the ability of the CS to predict US occurrence. Associative long-term potentiation (LTP), a cellular model of associative learning, occurs in the lateral nucleus of the amygdala (LA), the putative locus of plasticity in fear conditioning. Here we show that associative LTP in LA, like fear conditioning, is sensitive to stimulus… 

Amygdala, Long-term Potentiation, and Fear Conditioning

TLDR
These findings provide the most direct evidence yet available that the mechanisms of LTP are recruited in the experimental animals during behavioral training and that such mechanisms might be utilized for memory storage.

Out with the old and in with the new: Synaptic mechanisms of extinction in the amygdala

Central and basolateral amygdala neurons crash the aversive conditioning party: Theoretical comment on Rorick-Kehn and Steinmetz (2005).

TLDR
Results reveal that amygdala neurons are differentially engaged by aversive conditioning, but questions remain concerning the associative basis and functional role for these unit responses.

A role for midline and intralaminar thalamus in the associative blocking of Pavlovian fear conditioning

TLDR
An associative blocking design was used and results show an important role for MIT in predictive fear learning and are discussed with reference to previous findings implicating the midline and posterior intralaminar thalamus inFear learning and fear responding.

Metabotropic glutamate receptors are involved in amygdaloid plasticity

TLDR
These experiments show for the first time in vivo and in vitro that mGluR5 receptors are necessary for plasticity in the amygdala.
...

References

SHOWING 1-10 OF 15 REFERENCES

Fear conditioning induces associative long-term potentiation in the amygdala

TLDR
It is shown that fear conditioning alters auditory CS-evoked responses in LA in the same way as LTP induction, and these may underlie the long-term associative plasticity that constitutes memory of the conditioning experience.

A Synaptically Controlled, Associative Signal for Hebbian Plasticity in Hippocampal Neurons

TLDR
Action potentials provide a synaptically controlled, associative signal to the dendrites for Hebbian modifications of synaptic strength and induced a robust LTP in CA1 neurons.

Synaptic plasticity: LTP and LTD

Probability of shock in the presence and absence of CS in fear conditioning.

  • R. Rescorla
  • Psychology, Environmental Science
    Journal of comparative and physiological psychology
  • 1968
2 experiments indicate that CS-US contingency is an important determinant of fear conditioning and that presentation of US in the absence of CS interferes with fear conditioning. In Experiment 1,

L-Type Voltage-Gated Calcium Channels Mediate NMDA-Independent Associative Long-Term Potentiation at Thalamic Input Synapses to the Amygdala

TLDR
Thalamoamygdala LTP was independent of NMDA receptors, despite their presence at these synapses, and instead was dependent on L-type voltage-gated calcium channels, and it was synapse specific.

The influence of prior synaptic activity on the induction of long-term potentiation.

TLDR
The results suggest that the threshold for LTP induction may be continually adjusted according to the recent history of NMDA receptor activation and provide a physiological mechanism by which LTP can be transiently inhibited.

Hebbian synapses in hippocampus.

TLDR
The demonstrated spatiotemporal specificity of this pseudo-Hebbian conjunctive mechanism can account qualitatively for the known neurophysiological properties of associative long-term potentiation in these synapses, which in turn can explain the "cooperativity" requirement for long- term potentiation.

Emotion Circuits in the Brain

The field of neuroscience has, after a long period of looking the other way, again embraced emotion as an important research area. Much of the progress has come from studies of fear, and especially

Both Protein Kinase A and Mitogen-Activated Protein Kinase Are Required in the Amygdala for the Macromolecular Synthesis-Dependent Late Phase of Long-Term Potentiation

TLDR
Results suggest that PKA and MAPK are critical for the expression of a persistent phase of LTP in the lateral amygdala and that this late component requires the synthesis of new protein and mRNA.