Fe3O4@Au nanoparticles as a means of signal enhancement in surface plasmon resonance spectroscopy for thrombin detection

@article{Chen2015Fe3O4AuNA,
  title={Fe3O4@Au nanoparticles as a means of signal enhancement in surface plasmon resonance spectroscopy for thrombin detection},
  author={Hongxia Chen and Fangjie Qi and Hongjian Zhou and Shengsong Jia and Yanmin Gao and K. Koh and Yongmei Yin},
  journal={Sensors and Actuators B-chemical},
  year={2015},
  volume={212},
  pages={505-511}
}
Abstract The core-shell gold capped magnetic nanoparticles (GMPs) have been receiving increasing attention because of its optical and magnetic properties. In order to evaluate the ability of GMPs as a means of signal enhancement in surface plasmon resonance (SPR) spectroscopy, a sandwich SPR sensor is constructed by using thrombin as a model analyte. In this design, thrombin is captured by thrombin aptamer 1 (Apt1) and sensitively detected through addition of GMPs-Apt2 conjugates. Compared with… Expand
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