Fe(III) and Co(III) centers with carboxamido nitrogen and modified sulfur coordination: lessons learned from nitrile hydratase.

@article{Harrop2004FeIIIAC,
  title={Fe(III) and Co(III) centers with carboxamido nitrogen and modified sulfur coordination: lessons learned from nitrile hydratase.},
  author={Todd C Harrop and Pradip K Mascharak},
  journal={Accounts of chemical research},
  year={2004},
  volume={37 4},
  pages={
          253-60
        }
}
Nitrile hydratase (NHase) is a non-heme Fe(III) or non-corrinoid Co(III) metalloenzyme with an unprecedented coordination sphere comprising deprotonated carboxamido nitrogens and modified Cys-S (-SO(-) and -SO(2)(-)) sulfurs. We have synthesized model complexes derived from designed ligands that contain these donor groups. The model complexes mimic almost all the intrinsic properties of the unique M(III) (M = Fe, Co) active site of NHase. Even a functional Co(III) model has been synthesized… CONTINUE READING

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