Fcr1p inhibits development of fluconazole resistance in Candida albicans by abolishing CDR1 induction.

@article{Shen2007Fcr1pID,
  title={Fcr1p inhibits development of fluconazole resistance in Candida albicans by abolishing CDR1 induction.},
  author={Hui Shen and Mao-Mao An and De Jun Wang and Zheng Xu and Jun-dong Zhang and Ping-hui Gao and Ying-ying Cao and Yong-bing Cao and Yuanying Jiang},
  journal={Biological & pharmaceutical bulletin},
  year={2007},
  volume={30 1},
  pages={68-73}
}
Overexpression of Candida drug resistance 1 (CDR1) gene in Candida albicans (C. albicans), an efflux pump, is one of the major mechanisms contributing to drug resistance. C. albicans for fluconazole resistance 1 protein (Fcr1p) is a member of the family of zinc cluster proteins homologous to Pdr1p and Pdr3p (pleiotropic drug resistance protein) mediating azole resistance in Saccharomyces cerevisiae (S. cerevisiae) by regulating the expression of pleiotropic drug resistance 5 (PDR5) homologous… CONTINUE READING

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