FcgammaRIIB regulates autoreactive primary antibody-forming cell, but not germinal center B cell, activity.

@article{Rahman2007FcgammaRIIBRA,
  title={FcgammaRIIB regulates autoreactive primary antibody-forming cell, but not germinal center B cell, activity.},
  author={Ziaur S. M. Rahman and Boris Alabyev and Tim L Manser},
  journal={Journal of immunology},
  year={2007},
  volume={178 2},
  pages={897-907}
}
The low-affinity FcR for IgG FcgammaRIIB suppresses the development of IgG autoantibodies and autoimmune disease in normal individuals, but how this effect is mediated is incompletely understood. To investigate this issue, we created FcgammaRIIB-deficient versions of two previously described targeted BCR-transgenic lines of mice that contain follicular B cells with specificity for the hapten arsonate, but with different levels of antinuclear autoantigen reactivity. The primary development and… CONTINUE READING

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