FcgammaRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling.

@article{Kono2005FcgammaRIIBIT,
  title={FcgammaRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling.},
  author={Hajime Kono and Chieko Kyogoku and Takeshi Suzuki and Naoyuki Tsuchiya and Hiroaki Honda and Kazuhiko Yamamoto and Katsushi Tokunaga and Zen-ichiro Honda},
  journal={Human molecular genetics},
  year={2005},
  volume={14 19},
  pages={2881-92}
}
The B cell inhibitory receptor FcgammaRIIB plays crucial roles in the maintenance of self-tolerance. We have identified a polymorphism FCGR2B c.695T>C that results in the non-conservative replacement of 232Ile at the transmembrane helix to Thr and demonstrated the association of the polymorphism with susceptibility to systemic lupus erythematosus (SLE) in Asians. In this study, we examined the impact of FCGR2B c.695T>C on the functional properties of FcgammaRIIB by expressing each allele… CONTINUE READING

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