FcgammaR-mediated phagocytosis by human macrophages involves Hck, Syk, and Pyk2 and is augmented by GM-CSF.

@article{Kedzierska2001FcgammaRmediatedPB,
  title={FcgammaR-mediated phagocytosis by human macrophages involves Hck, Syk, and Pyk2 and is augmented by GM-CSF.},
  author={Katherine Kedzierska and N J Vardaxis and Anthony Jaworowski and Suzanne M. Crowe},
  journal={Journal of leukocyte biology},
  year={2001},
  volume={70 2},
  pages={322-8}
}
The receptors for the constant region of immunoglobulin G (FcgammaR) are widely expressed on cells of hemopoietic lineage and plays an important role in host defense. We investigated the signaling pathways during FcgammaR-mediated phagocytosis in human monocyte-derived macrophages (MDMs) and examined the effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on these events. FcgammaR-mediated phagocytosis resulted in enhanced tyrosine phosphorylation of a wide range of cellular… CONTINUE READING
7 Citations
0 References
Similar Papers

Citations

Publications citing this paper.

Similar Papers

Loading similar papers…