FcRn in the yolk sac endoderm of mouse is required for IgG transport to fetus.

@article{Kim2009FcRnIT,
  title={FcRn in the yolk sac endoderm of mouse is required for IgG transport to fetus.},
  author={Jonghan Kim and Sudhasri Mohanty and Latha P Ganesan and Keding Hua and David Jarjoura and W. Hayton and John M. Robinson and Clark Anderson},
  journal={Journal of immunology},
  year={2009},
  volume={182 5},
  pages={
          2583-9
        }
}
In adults, the nonclassical MHC class I molecule, FcRn, binds both IgG and albumin and rescues both from a degradative fate, endowing both proteins with high plasma concentrations. FcRn also transports IgG from mother to young during gestation. Anticipating that a detailed understanding of gestational IgG transport in the mouse may give us a useful model to understand FcRn function in the human placenta, we have studied FcRn in the mouse yolk sac placenta in detail. Analyzing day 19-20 fetuses… CONTINUE READING

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