FcRL4 acts as an adaptive to innate molecular switch dampening BCR signaling and enhancing TLR signaling.

@article{Sohn2011FcRL4AA,
  title={FcRL4 acts as an adaptive to innate molecular switch dampening BCR signaling and enhancing TLR signaling.},
  author={Hae Won Sohn and Peter D Krueger and Randall S Davis and Susan K Pierce},
  journal={Blood},
  year={2011},
  volume={118 24},
  pages={6332-41}
}
Fc receptor-like 4 (FcRL4) is expressed on the surface of a subset of memory B cells (MBCs) located at sites of invading pathogens in mucosal lymphoid tissues in healthy individuals. Recently, FcRL4(+) MBCs were shown to be greatly increased in number in the peripheral blood of HIV-infected viremic individuals, in whom they are associated with B-cell exhaustion, and in individuals chronically reinfected with malaria. In the present study, we provide evidence that the expression of FcRL4 in… CONTINUE READING

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