Fc receptors and immunoglobulin binding factors 1

@article{Fridman1991FcRA,
  title={Fc receptors and immunoglobulin binding factors 1},
  author={Wolf Herman Fridman},
  journal={The FASEB Journal},
  year={1991},
  volume={5},
  pages={2684 - 2690}
}
  • W. Fridman
  • Published 1 September 1991
  • Biology, Medicine
  • The FASEB Journal
Receptors for the Fc portion of Ig (Fc receptors, FcR) are found on all cell types of the immune system. Three types of FcR react with IgG: FcγRI is a high‐affinity receptor binding IgG monomers whereas FcγRII and FcγRIII are low‐affinity receptors binding IgG immune complexes; the three types of FcγR are members of the Ig superfamily. Two FcR react with IgE: Fc∊RI is a multichain receptor binding IgE with high affinity; it is composed of an IgE‐binding α chain, homologous to FcγRIII, and of… 
Fc receptors and their interactions with immunoglobulins.
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The current knowledge of the structures and functions of FcRn, pIgR, and the Fc gamma R and Fc epsilon RI proteins are summarized, concentrating on the interactions of the extracellular portions of these receptors with immunoglobulins.
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The Diverse Functions of the Ubiquitous Fcγ Receptors and Their Unique Constituent, FcRγ Subunit
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The finding that FcRγ derived from natural cytotoxicity triggering receptor 1 (NCR1) curtails CD8+ T cell expansion and thereby turns an acute viral infection into a chronic one opens a new avenue for targeting the FcγRs as one of the therapeutic regimens to boost the immune response.
Crystal Structure of Fcγ Receptor I and Its Implication in High Affinity γ-Immunoglobulin Binding*
TLDR
This study suggests a molecular mechanism for the high affinity IgG recognition by FcγRI and provides a structural basis for understanding its physiological function and its therapeutic implication in treating autoimmune diseases.
The therapeutical approaches for rare diseases through the immune processes of IgG Fc Receptors
TLDR
The characterisation of Fcαγs from genotype to phenotype and the Fcγs associated Rare diseases including cancers from laboratory bench to clinical bedside are discussed.
Evaluation of Fc Receptor Genes in Bovine Neutrophils
TLDR
Evaluated genetic variation and the impact of IgG binding on transcription of FcγR and secreted levels of phosphorylated Syk between Holstein-Friesian and Jersey X Holstein cows found to be related to breed differences in cows and impact downstream cellular function binding of Igg to Fc receptors.
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The cloning of a polypeptide identical to the gamma-chains of Fc epsilon RI, from mouse macrophages that do not express this receptor is reported, showing that these gamma- chains associate with one of the macrophage receptors (Fc gamma RIIa).
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
The findings on the FcγR III raise the question of how a PIG-tailed protein important in immune complex clearance in vivo and in antibody-dependent killing mediates ligand internalization and cytotoxicity.
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