Fc receptor-induced expression of Fas ligand on activated NK cells facilitates cell-mediated cytotoxicity and subsequent autocrine NK cell apoptosis.

@article{Eischen1996FcRE,
  title={Fc receptor-induced expression of Fas ligand on activated NK cells facilitates cell-mediated cytotoxicity and subsequent autocrine NK cell apoptosis.},
  author={Christine M. Eischen and Joel D Schilling and David H. Lynch and Peter Heinrich Krammer and Paul J. Leibson},
  journal={Journal of immunology},
  year={1996},
  volume={156 8},
  pages={2693-9}
}
Ligation of the Fc gamma R on NK cells by Ab-coated target cells initiates a mode of killing referred to as antibody-dependent cell-mediated cytotoxicity (ADCC). There is clear evidence that the release from NK cells of granules containing pore-forming proteins and serine proteases can result in the rapid (within minutes) cell death of Ab-coated targets. However, little information is available as to whether NK cells can initiate subsequent killing through granule-independent mechanisms and as… CONTINUE READING

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