Fc-gamma receptor cross-linking by immune complexes induces matrix metalloproteinase-1 in U937 cells via mitogen-activated protein kinase.

@article{Huang2000FcgammaRC,
  title={Fc-gamma receptor cross-linking by immune complexes induces matrix metalloproteinase-1 in U937 cells via mitogen-activated protein kinase.},
  author={Yuxiang Huang and Andrew H. Fleming and Shan Wu and Gabriel Virella and Maria F. Lopes-Virella},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2000},
  volume={20 12},
  pages={
          2533-8
        }
}
Matrix metalloproteinase-1 (MMP-1) secreted by macrophages potentially contributes to plaque rupture. Because large quantities of immunoglobulin G and ICs (ICs), including low density lipoprotein-containing ICs (LDL-ICs), are present in atherosclerotic lesions, we examined the effect of LDL-ICs on macrophage MMP-1 expression. With the use of ICs prepared with human LDL and rabbit anti-LDL antiserum, our enzyme-linked immunosorbent assays and Northern blots showed that MMP-1 secretion and… CONTINUE READING
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