Fc gamma receptor IIB on follicular dendritic cells regulates the B cell recall response.

@article{Qin2000FcGR,
  title={Fc gamma receptor IIB on follicular dendritic cells regulates the B cell recall response.},
  author={Dahui Qin and Jun-ying Wu and Kalpit A Vora and Jeffrey V Ravetch and Andras K. Szakal and Tim L Manser and J. Grant Tew},
  journal={Journal of immunology},
  year={2000},
  volume={164 12},
  pages={6268-75}
}
Generation of the B cell recall response appears to involve interaction of Ag, in the form of an immune complex (IC) trapped on follicular dendritic cells (FDCs), with germinal center (GC) B cells. Thus, the expression of receptors on FDC and B cells that interact with ICs could be critical to the induction of an optimal recall response. FDCs in GCs, but not in primary follicles, express high levels of the IgG Fc receptor Fc gamma RIIB. This regulated expression of Fc gamma RIIB on FDC and its… CONTINUE READING