Fc-based cytokines : prospects for engineering superior therapeutics.

@article{Jazayeri2008FcbasedC,
  title={Fc-based cytokines : prospects for engineering superior therapeutics.},
  author={Jalal A. Jazayeri and Graeme J Carroll},
  journal={BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy},
  year={2008},
  volume={22 1},
  pages={
          11-26
        }
}
The application of Fc (fragment crystallizable)-based cytokines (the fusion of the constant region of IgG to a cytokine of interest) as biotherapeutic agents to modulate inflammatory and immune responses has become increasingly popular in recent years. This is because in their monomeric form, cytokines are relatively small molecules with short serum half-lives, which necessitates frequent administration and thus limits their clinical utility. To rectify the problem, attempts have been made to… CONTINUE READING

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