FcγRIIb on myeloid cells and intrinsic renal cells rather than B cells protects from nephrotoxic nephritis.

@article{Sharp2013FcRIIbOM,
  title={FcγRIIb on myeloid cells and intrinsic renal cells rather than B cells protects from nephrotoxic nephritis.},
  author={Phoebe E H Sharp and Javier Martin-Ramirez and Sara M Mangsbo and P{\'e}ter Boross and Charles D Pusey and Ivo P. Touw and H Terence Cook and J. Sjef Verbeek and Ruth M. Tarzi},
  journal={Journal of immunology},
  year={2013},
  volume={190 1},
  pages={
          340-8
        }
}
FcγRIIb is the sole inhibitory FcR for IgG in humans and mice, where it is involved in the negative regulation of Ab production and cellular activation. FcγRIIb-deficient mice show exacerbated disease following the induction of nephrotoxic nephritis (NTN). In this study, we determined the cellular origin of the FcγRIIb-knockout phenotype by inducing NTN in mice with a deficiency of FcγRIIb on either B cells alone (FcγRIIB(fl/fl)/CD19Cre(+)) or myeloid cells (FcγRIIB(fl/fl)/CEBPαCre… CONTINUE READING

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