FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease.

  title={FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease.},
  author={T. Kam and Sungmin Song and Youngdae Gwon and Hyejin Park and J J Yan and Isak Im and Ji-Woo Choi and Tae-Yong Choi and JeongYeon Kim and D K Song and Toshiyuki Takai and Yong-Chul Kim and Key-Sun Kim and Se-Young Choi and Sukwoo Choi and William L. Klein and Junying Yuan and Yong-Keun Jung},
  journal={The Journal of clinical investigation},
  volume={123 7},
Amyloid-β (Aβ) induces neuronal loss and cognitive deficits and is believed to be a prominent cause of Alzheimer's disease (AD); however, the cellular pathology of the disease is not fully understood. Here, we report that IgG Fcγ receptor II-b (FcγRIIb) mediates Aβ neurotoxicity and neurodegeneration. We found that FcγRIIb is significantly upregulated in the hippocampus of AD brains and neuronal cells exposed to synthetic Aβ. Neuronal FcγRIIb activated ER stress and caspase-12, and Fcgr2b KO… CONTINUE READING
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