Fcγ receptors: structure, function and role as genetic risk factors in SLE

  title={Fcγ receptors: structure, function and role as genetic risk factors in SLE},
  author={Xingfeng Li and Travis S. Ptacek and Elizabeth E. Brown and Jeff C. Edberg},
  journal={Genes and Immunity},
Over 30 years ago, receptors for the Fc region of IgG (FcγR) were implicated in the pathogenesis of systemic lupus erythematosus (SLE). Since those pioneering studies, our knowledge of the structure and function of these FcγRs has increased dramatically. We now know that FcγR contributes to the regulation of acquired immunity and to the regulation of innate immune responses where FcγRs act as specific receptors for innate opsonins (CRP and SAP). Our understanding of the genomic architecture of… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 39 extracted citations

Monocyte and Macrophage Abnormalities in Systemic Lupus Erythematosus

Archivum Immunologiae et Therapiae Experimentalis • 2010
View 7 Excerpts
Highly Influenced

iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling.

The Journal of clinical investigation • 2018
View 1 Excerpt

CD16 and CD32 Gene Polymorphisms May Contribute to Risk of Idiopathic Thrombocytopenic Purpura

Medical science monitor : international medical journal of experimental and clinical research • 2016
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 90 references

Association of systemic lupus erythematosus with C 8 orf 13BLK and ITGAMITGAX

G Hom, RR Graham, +3 authors S Garnier
N Engl J Med • 2008

Similar Papers

Loading similar papers…