Fcγ receptors: structure, function and role as genetic risk factors in SLE

@article{Li2009FcRS,
  title={Fcγ receptors: structure, function and role as genetic risk factors in SLE},
  author={Xingfeng Li and Travis S. Ptacek and Elizabeth E. Brown and Jeff C. Edberg},
  journal={Genes and Immunity},
  year={2009},
  volume={10},
  pages={380-389}
}
Over 30 years ago, receptors for the Fc region of IgG (FcγR) were implicated in the pathogenesis of systemic lupus erythematosus (SLE). Since those pioneering studies, our knowledge of the structure and function of these FcγRs has increased dramatically. We now know that FcγR contributes to the regulation of acquired immunity and to the regulation of innate immune responses where FcγRs act as specific receptors for innate opsonins (CRP and SAP). Our understanding of the genomic architecture of… CONTINUE READING

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