Fcγ Receptor Function and the Design of Vaccination Strategies.

  title={Fcγ Receptor Function and the Design of Vaccination Strategies.},
  author={Stylianos Bournazos and Jeffrey V Ravetch},
  volume={47 2},
Through specific interactions with distinct types of Fcγ receptors (FcγRs), the Fc domain of immunoglobulin G (IgG) mediates a wide spectrum of immunological functions that influence both innate and adaptive responses. Recent studies indicate that IgG Fc-FcγR interactions are dynamically regulated during an immune response through the control of the Fc-associated glycan structure and Ig subclass composition on the one hand and selective FcγR expression on immune cells on the other, which… CONTINUE READING
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