Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver.

@article{Onoyama2011Fbxw7RL,
  title={Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver.},
  author={Ichiro Onoyama and Atsushi Suzuki and Akinobu Matsumoto and Kengo Tomita and Hideki Katagiri and Yuichi Oike and Keiichi I Nakayama},
  journal={The Journal of clinical investigation},
  year={2011},
  volume={121 1},
  pages={342-54}
}
E3 ubiquitin ligase complexes of the SCF type consist of ring-box 1 (Rbx1), cullin 1 (Cul1), S-phase kinase-associated protein 1 (Skp1), and a member of the F-box family of proteins. The identity of the F-box protein determines the substrate specificity of the complex. The F-box family member F-box- and WD repeat domain-containing 7 (Fbxw7; also known as Fbw7, SEL-10, hCdc4, and hAgo) targets for degradation proteins with wide-ranging functions, and uncovering its in vivo role has been… CONTINUE READING
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