Fbw7 targets GATA3 through cyclin-dependent kinase 2-dependent proteolysis and contributes to regulation of T-cell development.

Abstract

Proper development of T cells depends on lineage-specific regulators controlled transcriptionally and posttranslationally to ensure precise levels at appropriate times. Conditional inactivation of F-box protein Fbw7 in mouse T-cell development resulted in reduced thymic CD4 single-positive (SP) and splenic CD4(+) and CD8(+) cell proportions. Fbw7 deficiency… (More)

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@article{Kitagawa2014Fbw7TG, title={Fbw7 targets GATA3 through cyclin-dependent kinase 2-dependent proteolysis and contributes to regulation of T-cell development.}, author={Kyoko Kitagawa and Kiyoshi Shibata and Akinobu Matsumoto and Masaki Matsumoto and Tatsuya Ohhata and K. Nakayama and Hiroyuki Niida and Masatoshi Kitagawa}, journal={Molecular and cellular biology}, year={2014}, volume={34 14}, pages={2732-44} }