Favoring the risk-benefit balance for upper extremity transplantation--the Pittsburgh Protocol.


Upper extremity transplantation is an innovative reconstructive strategy with potential of immediate clinical application and the most near-term pay-off for select amputees, allowing reintegration into employment and society. Routine applicability and widespread impact of such strategies for the upper extremity amputees with devastating limb loss could be enabled by implementation of cellular therapies that integrate and unify the concepts of transplant tolerance induction with those of reconstructive transplantation. Such therapies offer the promise of minimizing the risks, maximizing the benefits and optimizing outcomes of these innovative procedures.

DOI: 10.1016/j.hcl.2011.08.008
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@article{Gorantla2011FavoringTR, title={Favoring the risk-benefit balance for upper extremity transplantation--the Pittsburgh Protocol.}, author={Vijay Gorantla and Gerald Brandacher and Stefan Schneeberger and Xin Xiao Zheng and Albert D. Donnenberg and Joseph E. Losee and Wei-Ping Lee}, journal={Hand clinics}, year={2011}, volume={27 4}, pages={511-20, ix-x} }