Efficacy and safety of metformin and pioglitazone in patients with coronary heart disease and type 2 diabetes mellitus
- Shaenko ZA, Racine MS
- Int. Endocrinol. J. 2(66),
email@example.com Background Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance, β cell failure, and microvascular and macrovascular complications. There is a two-fold to fourfold increased risk of a macrovascular event in patients with, compared with those without, diabetes . Heart disease was listed as the most frequent and was represented 69.5% of death cases of people with diabetes . Furthermore, diabetes mellitus predisposes people to premature atherosclerotic coronary artery disease (CAD) – another leading cause of mortality . Factors such as diabetes-associated hypertension and dyslipidemia may contribute to the severity of vascular dysfunction in diabetes. Endothelial dysfunction may play a role in the progression of coronary atherosclerosis and these people are at increased risk for cardiac events .