• Corpus ID: 132228437

Favismo: deficiencia de glucosa - 6- fosfato deshidrogenasa

  title={Favismo: deficiencia de glucosa - 6- fosfato deshidrogenasa},
  author={Sara D{\'i}ez de Fuentes},
Favism is an hereditary disorder responsible for acute hemolysis ocurring in glucose-6phosphate deydrogenase deficient (G6PDH) individual after eating or taking glycosides vicina and convicina, beta-glucosides which are compounds of Vicia faba. The deficiency is caused by changes in G-6PDH aminoacid sequence. Pentose-phosphate pathway provides reducing power in the form of NADPH +H + and this cofactor can preserve the reduced form of glutathione (GSH); GSH acts as a reducing agent in the red… 


Mechanism of Action of Divicine in a Cell-free System and in Glucose-6-phosphate Dehydrogenase-deficient Red Cells
There is almost complete correspondence between D effects and RBC changes during the favic crisis, and increased erythrophagocylosis, membrane cross-bonding, and formation of Heinz bodies seem to be causally related with the hemolytic process.
Oxidative stress and antioxidant defense in Egyptian favism patients.
It could be concluded that the favic patients have high oxidative stress (H2O2 and MDA) more than normal individuals and less antioxidant defense (GSH) with the passage of time these individuals, cells would be more vulnerable for H 2O2-induced senescence.
The chemistry of favism-inducing compounds. The properties of isouramil and divicine and their reaction with glutathione.
Red blood cells deficient in glucose-6-phosphate dehydrogenase cannot cope with such an oxidative challenge exerted by the pyrimidines, Consequently an irreversible cellular damage can take place leading to the enhanced sequestration of these red blood cells by the reticuloendothelial system.
Severe hemolysis and methemoglobinemia following fava beans ingestion in glucose-6-phosphatase dehydrogenase deficiency—case report and literature review
A previously healthy boy who presented with combined severe hemolytic anemia and cyanosis due to methemoglobinemia, following the ingestion of fava beans is reported.
Implicações do estresse oxidativo sobre o metabolismo eritrocitário de pessoas com Síndrome de Down
Down's Syndrome carriers are under endogenous and chronic oxidative stress that can result from an excessive SOD-1enzyme activity, and the presence of oxidative stress induced several adaptations of the erythrocyte metabolism, with a reduction of methemoglobin, through an increase of meethemoglobin reductase activity, which guaranteed the efficiency of oxygen transportation.
Life and Death of Glucose-6-Phosphate Dehydrogenase (G6PD) Deficient Erythrocytes – Role of Redox Stress and Band 3 Modifications
In summary, RBC membranes isolated from favic patients contained elevated amounts of complexes between IgG and the complement fragment C3b/C3c and were prone to vesiculation and anti-band 3 IgG reacted to aggregated band 3-complement complexes in favism.
Insuficiencia renal aguda secundaria como manifestación inicial de favismo en un adulto mayor. Caso Clínico.
A 67-year-old man presenting with abdominal pain of acute onset, pallor, jaundice and behavioral changes after ingestion of fava beans is reported, who was discharged without anemia and with normal renal function.
Evaluation of liver and kidney function in favism patients
Background G6PD deficiency is the most common enzymopathy of red blood cells. The clinical symptoms of favism are jaundice, hematuria and haemolytic anaemia that seem to affect liver and kidney in
Hydrolysis of vicine and convicine from fababeans by microbial beta-glucosidase enzymes.
  • A. M. Mckay
  • Biology
    The Journal of applied bacteriology
  • 1992
A potential use of micro-organisms or microbial enzymes for detoxification of fababeans is suggested, which results in complete degradation of the glycosides.