• Corpus ID: 132228437

Favismo: deficiencia de glucosa - 6- fosfato deshidrogenasa

@inproceedings{Fuentes2016FavismoDD,
  title={Favismo: deficiencia de glucosa - 6- fosfato deshidrogenasa},
  author={Sara D{\'i}ez de Fuentes},
  year={2016}
}
Favism is an hereditary disorder responsible for acute hemolysis ocurring in glucose-6phosphate deydrogenase deficient (G6PDH) individual after eating or taking glycosides vicina and convicina, beta-glucosides which are compounds of Vicia faba. The deficiency is caused by changes in G-6PDH aminoacid sequence. Pentose-phosphate pathway provides reducing power in the form of NADPH +H + and this cofactor can preserve the reduced form of glutathione (GSH); GSH acts as a reducing agent in the red… 

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TLDR
There is almost complete correspondence between D effects and RBC changes during the favic crisis, and increased erythrophagocylosis, membrane cross-bonding, and formation of Heinz bodies seem to be causally related with the hemolytic process.
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TLDR
It could be concluded that the favic patients have high oxidative stress (H2O2 and MDA) more than normal individuals and less antioxidant defense (GSH) with the passage of time these individuals, cells would be more vulnerable for H 2O2-induced senescence.
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TLDR
Red blood cells deficient in glucose-6-phosphate dehydrogenase cannot cope with such an oxidative challenge exerted by the pyrimidines, Consequently an irreversible cellular damage can take place leading to the enhanced sequestration of these red blood cells by the reticuloendothelial system.
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TLDR
A previously healthy boy who presented with combined severe hemolytic anemia and cyanosis due to methemoglobinemia, following the ingestion of fava beans is reported.
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TLDR
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TLDR
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TLDR
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    The Journal of applied bacteriology
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TLDR
A potential use of micro-organisms or microbial enzymes for detoxification of fababeans is suggested, which results in complete degradation of the glycosides.
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