Favipiravir (T-705) Inhibits Junín Virus Infection and Reduces Mortality in a Guinea Pig Model of Argentine Hemorrhagic Fever

@inproceedings{Gowen2013FavipiravirI,
  title={Favipiravir (T-705) Inhibits Jun{\'i}n Virus Infection and Reduces Mortality in a Guinea Pig Model of Argentine Hemorrhagic Fever},
  author={Brian B. Gowen and Terry L. Juelich and Eric J. Sefing and Trevor L Brasel and Jennifer K. Smith and Lihong Zhang and Bersabeh Tigabu and Terence E. Hill and Tatyana E. Yun and Colette A. Pietzsch and Yousuke Furuta and Alexander N. Freiberg},
  booktitle={PLoS neglected tropical diseases},
  year={2013}
}
BACKGROUND Junín virus (JUNV), the etiologic agent of Argentine hemorrhagic fever (AHF), is classified by the NIAID and CDC as a Category A priority pathogen. Presently, antiviral therapy for AHF is limited to immune plasma, which is readily available only in the endemic regions of Argentina. T-705 (favipiravir) is a broadly active small molecule RNA-dependent RNA polymerase inhibitor presently in clinical evaluation for the treatment of influenza. We have previously reported on the in vitro… CONTINUE READING
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