Fatty liver in heterozygous hypobetalipoproteinemia caused by a novel truncated form of apolipoprotein B.

@article{Tarugi1996FattyLI,
  title={Fatty liver in heterozygous hypobetalipoproteinemia caused by a novel truncated form of apolipoprotein B.},
  author={Patrizia Tarugi and Amedeo Lonardo and Giorgia Ballarini and Alberto Grisendi and Manuela Pulvirenti and Alberto Bagni and Sebastiano Calandra},
  journal={Gastroenterology},
  year={1996},
  volume={111 4},
  pages={1125-33}
}
Fatty liver has been anecdotally associated with heterozygous hypobetalipoproteinemia. The aim of this study was to characterize the molecular defect in a subject with heterozygous hypobetalipoproteinemia (low-density lipoprotein cholesterol, 52 mg/dL; apolipoprotein [apo] B, 15 mg/dL) and otherwise unexplained fatty liver. Plasma lipoproteins were separated by ultracentrifugation, and apo B was analyzed by electrophoresis and immunoblotting. A fragment of genomic DNA corresponding to the 5… CONTINUE READING

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