Fatty acylation promotes fusion of transport vesicles with Golgi cisternae

@article{Pfanner1990FattyAP,
  title={Fatty acylation promotes fusion of transport vesicles with Golgi cisternae},
  author={N Pfanner and B S Glick and S R Arden and James E Rothman},
  journal={The Journal of Cell Biology},
  year={1990},
  volume={110},
  pages={955 - 961}
}
  • N Pfanner, B S Glick, +1 author James E Rothman
  • Published 1990 in The Journal of cell biology
Two different methods, stimulation of transport by fatty acyl-coenzyme A (CoA) and inhibition of transport by a nonhydrolyzable analogue of palmitoyl-CoA, reveal that fatty acylation is required to promote fusion of transport vesicles with Golgi cisternae. Specifically, fatty acyl-CoA is needed after the attachment of coated vesicles and subsequent uncoating of the vesicles, and after the binding of the NEM-sensitive fusion protein (NSF) to the membranes, but before the actual fusion event. We… CONTINUE READING
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section of a single round of vesicular transport : sequential coated and uncoated intermediates mediate intercisternal movement in the Golgi stack

  • G. E. Palade
  • Cell .
  • 1989

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