Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins.

Covalent attachment of myristate and/or palmitate occurs on a wide variety of viral and cellular proteins. This review will highlight the latest advances in our understanding of the enzymology of N-myristoylation and palmitoylation as well as the functional consequences of fatty acylation of key signaling proteins. The role of myristate and palmitate in… CONTINUE READING