Fatty acids regulate pigmentation via proteasomal degradation of tyrosinase: a new aspect of ubiquitin-proteasome function.

@article{Ando2004FattyAR,
  title={Fatty acids regulate pigmentation via proteasomal degradation of tyrosinase: a new aspect of ubiquitin-proteasome function.},
  author={Hideya Ando and Hidenori Watabe and Julio C. Valencia and Ken-ichi Yasumoto and Minao Furumura and Yoko Funasaka and Masahiro Oka and Masamitsu Ichihashi and Vincent J. Hearing},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 15},
  pages={15427-33}
}
Fatty acids are common components of biological membranes that are known to play important roles in intracellular signaling. We report here a novel mechanism by which fatty acids regulate the degradation of tyrosinase, a critical enzyme associated with melanin biosynthesis in melanocytes and melanoma cells. Linoleic acid (unsaturated fatty acid, C18:2) accelerated the spontaneous degradation of tyrosinase, whereas palmitic acid (saturated fatty acid, C16:0) retarded the proteolysis. The… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

Similar Papers

Loading similar papers…