Fatty acids liberated from high-density lipoprotein phospholipids by endothelial-derived lipase are incorporated into lipids in HepG2 cells.

@article{Strauss2003FattyAL,
  title={Fatty acids liberated from high-density lipoprotein phospholipids by endothelial-derived lipase are incorporated into lipids in HepG2 cells.},
  author={Juliane Gertrude Strauss and Marianne Hayn and Rudolt Zechner and Sanja Levak-Frank and Sa{\vs}a Frank},
  journal={The Biochemical journal},
  year={2003},
  volume={371 Pt 3},
  pages={981-8}
}
We previously reported that endothelial-derived lipase (EDL) efficiently hydrolyses high-density-lipoprotein-derived phosphatidycholine (HDL-PC). In the present study, we assessed the ability of EDL to supply HepG2 cells with non-esterified fatty acids (NEFA) liberated from HDL-phospholipids. For this purpose, HepG2 cells infected with adenovirus encoding human EDL (EDL-Ad), or with control beta-galactosidase-expressing adenovirus (LacZ-Ad), were incubated with (14)C-HDL-PC. The analysis of the… CONTINUE READING

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