Fatty acids inhibit insulin-mediated glucose transport associated with actin remodeling in rat L6 muscle cells

@article{Zhao2010FattyAI,
  title={Fatty acids inhibit insulin-mediated glucose transport associated with actin remodeling in rat L6 muscle cells},
  author={Hai-Lu Zhao and Li-zhong Liu and Yi Sui and Stanley S. K. Ho and Shuk-Kuen Tam and Fernand Mac-Moune Lai and Juliana C. N. Chan and Peter C. Y. Tong},
  journal={Acta Diabetologica},
  year={2010},
  volume={47},
  pages={331-339}
}
In skeletal muscle cells, insulin stimulates cytoskeleton actin remodeling to facilitate the translocation of glucose transporter GLUT4 to plasma membrane. Defect of insulin-induced GLUT4 translocation and actin remodeling may cause insulin resistance. Free fatty acids cause insulin resistance in skeletal muscle. The aim of this study was to investigate the effects of fatty acids on glucose transport and actin remodeling. Differentiated L6 muscle cells expressing c-myc epitope-tagged GLUT4 were… CONTINUE READING

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