Fatty acids induce chloride permeation in rat liver mitochondria by activation of the inner membrane anion channel (IMAC).

@article{Schnfeld2004FattyAI,
  title={Fatty acids induce chloride permeation in rat liver mitochondria by activation of the inner membrane anion channel (IMAC).},
  author={Peter Sch{\"o}nfeld and Iqbal Sayeed and Ralf Bohnensack and Detlef Siemen},
  journal={Journal of bioenergetics and biomembranes},
  year={2004},
  volume={36 3},
  pages={241-8}
}
The inner membrane of freshly isolated mammalian mitochondria is poorly permeable to Cl(-). Low, nonlytic concentrations (< or =30 microM) of long-chain fatty acids or their branched-chain derivatives increase permeation of Cl(-) as indicated from rapid large-scale swelling of mitochondria suspended in slightly alkaline KCl medium (supplemented with valinomycin). Myristic, palmitic, or 5-doxylstearic acid are powerful inducers of Cl(-) permeation, whereas lauric, phytanic, stearic, or 16… CONTINUE READING

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