Fatty acids in Botryococcus braunii accelerate topical delivery of flurbiprofen into and across skin.

@article{Fang2004FattyAI,
  title={Fatty acids in Botryococcus braunii accelerate topical delivery of flurbiprofen into and across skin.},
  author={Jia-You Fang and Hsien-Chih Chiu and Jiunn-Tzong Wu and Yin-Ru Chiang and Shu-hui Hsu},
  journal={International journal of pharmaceutics},
  year={2004},
  volume={276 1-2},
  pages={
          163-73
        }
}
To improve the drug absorption into and across the skin, fatty acids extracted from Botryococcus braunii were evaluated using in vitro and in vivo techniques with Wistar rats as the animal model. Palmitic acid (C16:0), oleic acid (C18:1), linoleic acid (C18:2), and linolenic acid (C18:3) were the major components in the B. braunii extract. Topical delivery of flurbiprofen was significantly enhanced after pretreatment with 3% B. braunii extract for 30min in an in vitro Franz cell and in vivo… CONTINUE READING

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