Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids.

@article{Wall2010FattyAF,
  title={Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids.},
  author={Rebecca Wall and Reynolds Paul Ross and Gerald F. Fitzgerald and Catherine Stanton},
  journal={Nutrition reviews},
  year={2010},
  volume={68 5},
  pages={
          280-9
        }
}
Omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFA) are precursors of potent lipid mediators, termed eicosanoids, which play an important role in the regulation of inflammation. Eicosanoids derived from n-6 PUFAs (e.g., arachidonic acid) have proinflammatory and immunoactive functions, whereas eicosanoids derived from n-3 PUFAs [e.g., eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] have anti-inflammatory properties, traditionally attributed to their ability to inhibit… 
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982 Citations

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Role of Omega-3 Fatty Acid in Major Cardiovascular Events—A Current View

Although appearing to be a low-risk and cost-effective strategy to improve cardiac health, available evidence demonstrates that omega-3 PUFAs supplementation may be recommended in primary prevention of major cardiovascular events in patients free of known coronary heart disease (CHD), but with high risk.
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