Fatty acids differentially regulate insulin resistance through endoplasm reticulum stress-mediated induction of tribbles homologue 3: a potential link between dietary fat composition and the pathophysiological outcomes of obesity

@article{Geng2013FattyAD,
  title={Fatty acids differentially regulate insulin resistance through endoplasm reticulum stress-mediated induction of tribbles homologue 3: a potential link between dietary fat composition and the pathophysiological outcomes of obesity},
  author={Tuoyu Geng and Wei Hu and Margaret H Broadwater and Justin M Snider and Jacek Bielawski and Sarah Brice Russo and John Schwacke and Jessica Ross and L. Ashley Cowart},
  journal={Diabetologia},
  year={2013},
  volume={56},
  pages={2078-2087}
}
Previous studies have shown that saturated fatty acids cause insulin resistance (IR) that is prevented by unsaturated fatty acids. Tribbles homologue 3 (TRIB3) is a putative endogenous inhibitor of insulin signalling, but its role in insulin signalling is controversial. This study aimed to determine whether fatty acids regulate IR via TRIB3. We treated HepG2 cells with saturated and unsaturated fatty acids and evaluated TRIB3 expression. We then tested whether regulation of TRIB3 occurred… CONTINUE READING