Fatty acids differentially modulate insulin-stimulated endothelial nitric oxide production by an Akt-independent pathway.

@article{Lynn2004FattyAD,
  title={Fatty acids differentially modulate insulin-stimulated endothelial nitric oxide production by an Akt-independent pathway.},
  author={Matthew A Lynn and Heidi L. Rupnow and Dean J. Kleinhenz and William A. Kanner and Samuel C Dudley and Craig M Hart},
  journal={Journal of investigative medicine : the official publication of the American Federation for Clinical Research},
  year={2004},
  volume={52 2},
  pages={129-36}
}
BACKGROUND Insulin increases endothelial nitric oxide (NO) production by activating endothelial nitric oxide synthase (eNOS) through protein kinase B (Akt)-mediated phosphorylation of serine residue 1179 (p-eNOS serine 1179). Because fatty acids modulate insulin-stimulated Akt signaling cascades in smooth muscle cells, we hypothesized that fatty acids would differentially regulate endothelial Akt signaling, eNOS phosphorylation, and NO production. METHODS Porcine pulmonary artery endothelial… CONTINUE READING