Fatty acids change the conformation of uncoupling protein 1 (UCP1).

  title={Fatty acids change the conformation of uncoupling protein 1 (UCP1).},
  author={Ajit S Divakaruni and Dickon M. Humphrey and Martin D. Brand},
  journal={The Journal of biological chemistry},
  volume={287 44},
UCP1 catalyzes proton leak across the mitochondrial inner membrane to disengage substrate oxidation from ATP production. It is well established that UCP1 is activated by fatty acids and inhibited by purine nucleotides, but precisely how this regulation occurs remains unsettled. Although fatty acids can competitively overcome nucleotide inhibition in functional assays, fatty acids have little effect on purine nucleotide binding. Here, we present the first demonstration that fatty acids induce a… CONTINUE READING
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