Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.

@article{Keller1993FattyAA,
  title={Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.},
  author={H Keller and Christine Dreyer and Jeffrey A. Medin and Abderrahim Mahfoudi and Keiko Ozato and Walter Wahli},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90},
  pages={2160 - 2164}
}
  • H. Keller, C. Dreyer, +3 authors W. Wahli
  • Published 1993
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
The nuclear hormone receptors called PPARs (peroxisome proliferator-activated receptors alpha, beta, and gamma) regulate the peroxisomal beta-oxidation of fatty acids by induction of the acyl-CoA oxidase gene that encodes the rate-limiting enzyme of the pathway. Gel retardation and cotransfection assays revealed that PPAR alpha heterodimerizes with retinoid X receptor beta (RXR beta; RXR is the receptor for 9-cis-retinoic acid) and that the two receptors cooperate for the activation of the acyl… Expand
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