Fatty acids, triglycerides and syndromes of insulin resistance.

  title={Fatty acids, triglycerides and syndromes of insulin resistance.},
  author={Len H. Storlien and Adamandia D Kriketos and G Dennis Calvert and Louise A. Baur and Arthur B. Jenkins},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
  volume={57 4-5},
Muscle plays a major role in insulin-stimulated glucose disposal. There is now a range of evidence in humans and experimental animals demonstrating strong relationships between the fatty acid composition of structural membrane lipids and insulin action. The in vivo work is correlative but the in vitro studies suggest a causal relationship exists. Good insulin action is associated with an increased proportion of n-3 fatty acids, low saturates, a low n-6/n-3 ratio and possibly increased… CONTINUE READING