Fatty acid transport protein 4 is the principal very long chain fatty acyl-CoA synthetase in skin fibroblasts.

@article{Jia2007FattyAT,
  title={Fatty acid transport protein 4 is the principal very long chain fatty acyl-CoA synthetase in skin fibroblasts.},
  author={Zhenzhen Jia and Casey L. Moulson and Zhengtong Pei and Jeffrey H Miner and Paul A. Watkins},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 28},
  pages={
          20573-83
        }
}
Fatty acid transport protein 4 (FATP4) is a fatty acyl-CoA synthetase that preferentially activates very long chain fatty acid substrates, such as C24:0, to their CoA derivatives. To gain better insight into the physiological functions of FATP4, we established dermal fibroblast cell lines from FATP4-deficient wrinkle-free mice and wild type (w.t.) mice. FATP4 -/- fibroblasts had no detectable FATP4 protein by Western blot. Compared with w.t. fibroblasts, cells lacking FATP4 had an 83% decrease… CONTINUE READING

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