Fatty acid synthase knockout impairs early embryonic development via induction of endoplasmic reticulum stress in pigs.

Abstract

Fatty acid synthase (FAS) is an important enzyme involved in the de novo synthesis of long-chain fatty acids. During development, the function of FAS in growth is greater than that in energy storage pathways; therefore, we hypothesized that knockout of FAS would affect early embryonic development owing to the induction of endoplasmic reticulum (ER) stress… (More)
DOI: 10.1002/jcp.26241

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