Fatty acid synthase inhibition by amentoflavone induces apoptosis and antiproliferation in human breast cancer cells.

@article{Lee2009FattyAS,
  title={Fatty acid synthase inhibition by amentoflavone induces apoptosis and antiproliferation in human breast cancer cells.},
  author={Jin Sun Lee and Myung Sun Lee and Won Keun Oh and Ji Young Sul},
  journal={Biological & pharmaceutical bulletin},
  year={2009},
  volume={32 8},
  pages={1427-32}
}
Fatty acid synthase (FASN) is highly expressed in breast carcinomas to support their continuous growth and proliferation, but has low expression level in normal tissues. Considerable interest has been developed in searching for novel FASN inhibitors as a therapeutic target for breast cancer. In present study, amentoflavone was isolated from Selaginella tamariscina, a traditional oriental medicine that has been used to treat cancer for many years, and was found to significantly inhibit the in… CONTINUE READING

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