Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1.

@article{Furuta2008FattyAS,
  title={Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1.},
  author={Eiji Furuta and Sudha K. Pai and Rui Zhan and Sucharita Bandyopadhyay and Misako Watabe and Yin-yuan Mo and Shigeru Hirota and Sadahiro Hosobe and Taisei Tsukada and Kunio Miura and S Kamada and Ken Saito and Megumi Iiizumi and Wen Liu and Johan Ericsson and Kounosuke Watabe},
  journal={Cancer research},
  year={2008},
  volume={68 4},
  pages={
          1003-11
        }
}
The fatty acid synthase (FAS) gene is significantly up-regulated in various types of cancers, and blocking the FAS expression results in apoptosis of tumor cells. Therefore, FAS is considered to be an attractive target for anticancer therapy. However, the molecular mechanism by which the FAS gene is up-regulated in tumor cells is poorly understood. We found that FAS was significantly up-regulated by hypoxia, which was also accompanied by reactive oxygen species (ROS) generation in human breast… 

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