Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1.

@article{Furuta2008FattyAS,
  title={Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1.},
  author={E. Furuta and S. K. Pai and R. Zhan and S. Bandyopadhyay and M. Watabe and Y. Mo and S. Hirota and S. Hosobe and T. Tsukada and K. Miura and S. Kamada and K. Saito and Megumi Iiizumi and Wen Liu and J. Ericsson and K. Watabe},
  journal={Cancer research},
  year={2008},
  volume={68 4},
  pages={
          1003-11
        }
}
The fatty acid synthase (FAS) gene is significantly up-regulated in various types of cancers, and blocking the FAS expression results in apoptosis of tumor cells. Therefore, FAS is considered to be an attractive target for anticancer therapy. However, the molecular mechanism by which the FAS gene is up-regulated in tumor cells is poorly understood. We found that FAS was significantly up-regulated by hypoxia, which was also accompanied by reactive oxygen species (ROS) generation in human breast… Expand
Hypoxia upregulates the gene expression of mitochondrial aconitase in prostate carcinoma cells.
Reduced expression of FASN through SREBP‐1 down‐regulation is responsible for hypoxic cell death in HepG2 cells
Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth.
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