• Biology
  • Published 2017

Fatty acid synthase expression and inhibition in triple-negative breast cancer

  title={Fatty acid synthase expression and inhibition in triple-negative breast cancer},
  author={Ariadna Gir{\'o} Perafita},
Triple-negative breast cancer (TNBC) represents 20% of breast cancer and patients receive only general chemotherapy. The epidermal growth factor receptor (EGFR) is commonly expressed in TNBC and it is associated with poor prognosis. Fatty acid synthase (FASN) is overexpressed in cancer and its inhibition causes apoptosis in cancer cells. This thesis shows that FASN is overexpressed in TNBC, and its expression is associated with poor disease progression. In addition, FASN not only may have a… CONTINUE READING


Publications referenced by this paper.

Preclinical Evaluation of Fatty Acid Synthase and EGFR Inhibition in Triple-Negative Breast Cancer.

Chaffer, Cell plasticity and heterogeneity in cancer

  • N. D. Marjanovic, C.L.R. a. Weinberg
  • Clin. Chem
  • 2013

Expansion of breast cancer stem cells with fibrous scaffolds.

Dissecting the heterogeneity of triple-negative breast cancer.