Fatty acid metabolism as a target for obesity treatment

@article{Ronnett2005FattyAM,
  title={Fatty acid metabolism as a target for obesity treatment},
  author={G. Ronnett and Eun-Kyoung Kim and Leslie E. Landree and Yajun Tu},
  journal={Physiology \& Behavior},
  year={2005},
  volume={85},
  pages={25-35}
}
Although metabolites and energy balance have long been known to play roles in the regulation of food intake, the potential role of fatty acid metabolism in this process has been considered only recently. Fatty acid synthase (FAS) catalyzes the condensation of acetyl-CoA and malonyl-CoA to generate long-chain fatty acids in the cytoplasm, while the breakdown of fatty acids (beta-oxidation) occurs in mitochondria and is regulated by carnitine palmitoyltransferase-1 (CPT-1), the rate-limiting step… Expand
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C75, a Fatty Acid Synthase (FAS) Inhibitor
TLDR
What is known about hypothalamic fatty acid metabolism and the regulation of feeding is recapitulate, with particular interest in a specific FAS inhibitor, C75, which has been recently patented as a potential drug for adipose treatment. Expand
Increasing Fatty Acid Oxidation Remodels the Hypothalamic Neurometabolome to Mitigate Stress and Inflammation
TLDR
It is proposed that enhancing FAOx in hypothalamic neurons exposed to excess lipids promotes metabolic remodeling that reduces local inflammatory and cell stress responses and restore mitochondrial function such that increased FAOx can produce hypothalamic neuronal ATP and lead to decreased food intake and body weight to improve systemic metabolism. Expand
Phytochemicals in regulating fatty acid β-oxidation: Potential underlying mechanisms and their involvement in obesity and weight loss.
TLDR
Dietary phytochemicals and natural health products offer great potential as an efficient weight loss strategy by modulating lipid metabolism and/or increasing BMR and thermogenesis. Expand
The Effects of C75, an Inhibitor of Fatty Acid Synthase, on Sleep and Metabolism in Mice
TLDR
The findings suggest that sleep and metabolic effects of C75 in mice are independent of the ghrelin system and may be due to its aversive actions in mice. Expand
[Role of fatty acids in the nervous control of energy balance].
TLDR
FA overload might impair neural control of energy homeostasis through enhanced ceramide synthesis and may contribute to obesity and/or type 2 diabetes pathogenesis in predisposed subjects. Expand
Fatty Acid Synthase Inhibitors Modulate Energy Balance via Mammalian Target of Rapamycin Complex 1 Signaling in the Central Nervous System
TLDR
Findings collectively indicate an important interaction between the FAS and mTORC1 pathways in the central nervous system for regulating energy balance, possibly via modulation of neuronal glucose utilization. Expand
The Role of Hypothalamic Malonyl-CoA in Energy Homeostasis*
TLDR
A role for malonyl-CoA as an intermediary in the control of energy homeostasis is supported by physiologic, pharmacologic, and genetic evidence implicated in this energy-sensing system. Expand
Effects of β‐aminoisobutyric acid on leptin production and lipid homeostasis: mechanisms and possible relevance for the prevention of obesity
TLDR
The circumstances that led to the discovery of BAIBA, and recent data from other investigators suggesting that increasing leptin levels and/or responsiveness may be indeed an attractive pharmacological strategy in order to prevent (and/or treat) obesity, are recalled. Expand
Brain lipid sensing and the neural control of energy balance
TLDR
FA could overload energy homeostasis via increased hypothalamic ceramide synthesis which could, in turn, contribute to the pathogenesis of diabetes of obesity and/ or type 2 in predisposed individuals by disrupting the endocrine signaling pathways of insulin and/or leptin. Expand
The Effects of New Selective PPARα Agonist CP775146 on Systematic Lipid Metabolism in Obese Mice and Its Potential Mechanism
TLDR
CP775146 efficiently alleviates obesity-induced liver damage, prevents lipid accumulation by activating the liver fatty acid β-oxidation pathway, and regulates the expression of genes that control brown fat-like pathway in eWAT. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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