Fatty acid metabolism and the basis of brown adipose tissue function
@article{CaldernDomnguez2015FattyAM,
title={Fatty acid metabolism and the basis of brown adipose tissue function},
author={Mar{\'i}a Calder{\'o}n-Dom{\'i}nguez and Joan Francesc Mir and Raquel Fucho and Min{\'e}ia Weber and Dolors Serra and Laura Herrero},
journal={Adipocyte},
year={2015},
volume={5},
pages={98 - 118}
}ABSTRACT Obesity has reached epidemic proportions, leading to severe associated pathologies such as insulin resistance, cardiovascular disease, cancer and type 2 diabetes. Adipose tissue has become crucial due to its involvement in the pathogenesis of obesity-induced insulin resistance, and traditionally white adipose tissue has captured the most attention. However in the last decade the presence and activity of heat-generating brown adipose tissue (BAT) in adult humans has been rediscovered…
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226 References
Adipose tissue browning and metabolic health
- 2014
Biology, Medicine
Nature Reviews Endocrinology
Stimulating the development of beige adipocytes in WAT (so called 'browning') might reduce adverse effects of WAT and could help to improve metabolic health, as well as inspire new avenues to increase the capacity for adaptive thermogenesis.
Mitochondrial fatty acid oxidation in obesity.
- 2013
Medicine, Biology
Antioxidants & redox signaling
This review evaluates recent discoveries regarding mitochondrial fatty acid oxidation (FAO) and its potential as a therapy for obesity, focusing on the still controversial beneficial effects of increased FAO in liver and muscle.
Control of Brown Adipose Tissue Glucose and Lipid Metabolism by PPARγ
- 2011
Biology
Front. Endocrin.
Whereas BAT recruitment through sympathetic drive translates into functional thermogenic activity, PPARγ-mediated recruitment is associated with a reduction in sympathetic activity leading to increased lipid storage in brown adipocytes, and the promising therapeutic role of BAT in the treatment of hypertriglyceridemic and hyperglycemic conditions is discussed.
An endocrine role for brown adipose tissue?
- 2013
Biology
American journal of physiology. Endocrinology and…
Whether brown fat plays an endocrine role and, if so, to comprehensively identify which endocrine factors are released by BAT is investigated.
Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation
- 2007
Biology, Medicine
Diabetes
It is shown that adipose tissue of obese mice is hypoxic and that local adipose tissues hypoxia dysregulates the production of adipocytokines, and the results suggest that hypoperfusion and Hypoxia in adipose organs underlie the dysregulated production of fat-derived secretory factors and metabolic syndrome in obesity.
Pharmacological and nutritional agents promoting browning of white adipose tissue.
- 2013
Biology
Biochimica et biophysica acta
Obesity, inflammation, and insulin resistance.
- 2007
Medicine, Biology
Gastroenterology
The rapidly expanding body of animal and clinical data that support potential roles for inflammation in the pathogenesis of insulin resistance and type 2 diabetes mellitus are reviewed.
Brown adipose tissue activity controls triglyceride clearance
- 2011
Biology
Nature Medicine
It is shown that increased BAT activity induced by short-term cold exposure controls TRL metabolism in mice, and Activation of BAT might be a therapeutic approach to reduce elevated triglyceride concentrations and combat obesity in humans.
Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspective.
- 2010
Medicine, Biology
Biochimica et biophysica acta