Fatty acid-induced insulin resistance in adipocytes.

@article{EppsFung1997FattyAI,
  title={Fatty acid-induced insulin resistance in adipocytes.},
  author={M Van Epps-Fung and Jodie Williford and Alan Wells and Robert William Hardy},
  journal={Endocrinology},
  year={1997},
  volume={138 10},
  pages={
          4338-45
        }
}
Elevated serum-free fatty acid (FFA) levels induce insulin resistance in whole animals and humans. To understand the direct mechanism by which FFAs impact insulin-responsive tissue, we have used our previously developed in vitro model of long-chain saturated fatty acids (LCSFA)-induced insulin resistance in adipocytes. In addition to explanted rat adipocytes, we now demonstrate that overnight exposure of 3T3-L1 adipocytes to 1 mM individually of the LCSFA palmitate, myristate, and stearate… CONTINUE READING

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Epidermal growth factor induces glucose storage in transgenic 3 T 3 – L 1 adipocytes overexpressing epidermal growth factor receptors

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