Fatty acid-induced inflammation and insulin resistance in skeletal muscle and liver.

@article{Boden2006FattyAI,
  title={Fatty acid-induced inflammation and insulin resistance in skeletal muscle and liver.},
  author={Guenther Boden},
  journal={Current diabetes reports},
  year={2006},
  volume={6 3},
  pages={177-81}
}
Plasma free fatty acid (FFA) levels are elevated in obesity. FFA, by causing insulin resistance in muscle, liver, and endothelial cells, contributes to the development of type 2 diabetes mellitus (T2DM), hypertension, dyslipidemia, and nonalcoholic fatty liver disease (NAFLD). The mechanism through which FFA induces insulin resistance involves intramyocellular and intrahepatocellular accumulation of triglycerides and diacylglycerol, activation of several serine/threonine kinases, reduction in… CONTINUE READING
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